SERPINB6

SERPINB6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1M37
Identifiers
Aliases	SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin family B member 6
External IDs	OMIM: 173321 HomoloGene: 20956 GeneCards: SERPINB6
Gene location (Human) Chr. Chromosome 6 (human) Band 6p25.2 Start 2,948,159 bp End 2,972,165 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • protease binding • serine-type endopeptidase inhibitor activity Cellular component • ไซโทพลาซึม • ไซโตซอล • เอกโซโซมชนิดภายนอกเซลล์ • นิวเคลียสเซลล์ • ภายนอกเซลล์ • เยื่อหุ้มเซลล์ • secretory granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • extracellular region • สารเคลือบเซลล์ที่มีคอลลาเจนเป็นส่วนประกอบ • serine protease inhibitor complex Biological process • negative regulation of peptidase activity • sensory perception of sound • cellular response to osmotic stress • negative regulation of endopeptidase activity • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5269	n/a
Ensembl	ENSG00000124570	n/a
UniProt	P35237	n/a
RefSeq (mRNA)	NM_001195291 NM_001271822 NM_001271823 NM_001271824 NM_001271825 NM_001297699 NM_001297700 NM_004568 NM_001374515 NM_001374516 NM_001374517	n/a
RefSeq (protein)	NP_001182220 NP_001258751 NP_001258752 NP_001258753 NP_001258754 NP_001284628 NP_001284629 NP_004559 NP_001361444 NP_001361445 NP_001361446	n/a
Location (UCSC)	Chr 6: 2.95 – 2.97 Mb	n/a
PubMed search		n/a
Wikidata
View/Edit Human

เซอร์ปิน บี6 (อังกฤษ: Serpin B6 หรือ SERPINB6) เป็นโปรตีนของมนุษย์ และเป็นโปรตีนสมาชิกลำดับที่ 6 ในเคลดบีของมหาวงศ์เซอร์ปิน (Serpin family B member 6) ถูกถอดรหัสได้โดยยีน SERPINB6 บนโครโมโซมคู่ที่ 6

ดูเพิ่ม

• เซอร์ปิน

แหล่งข้อมูลอื่น

• Sun J, Coughlin P, Salem HH, Bird P (1995). "Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris". Biochim. Biophys. Acta. 1252 (1): 28–34. doi:10.1016/0167-4838(95)00108-7. PMID 7548163.
• Coughlin P, Nicholl J, Sun J, และคณะ (1995). "Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization". Genomics. 26 (2): 431–3. doi:10.1016/0888-7543(95)80240-M. PMID 7601482.
• Morgenstern KA, Sprecher C, Holth L, และคณะ (1994). "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases". Biochemistry. 33 (11): 3432–41. doi:10.1021/bi00177a037. PMID 8136380.
• Morgenstern KA, Henzel WJ, Baker JB, และคณะ (1993). "Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line". J. Biol. Chem. 268 (29): 21560–8. PMID 8408007.
• Coughlin PB, Tetaz T, Salem HH (1993). "Identification and purification of a novel serine proteinase inhibitor". J. Biol. Chem. 268 (13): 9541–7. PMID 8486644.
• Riewald M, Morgenstern KA, Schleef RR (1996). "Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins". J. Biol. Chem. 271 (12): 7160–7. doi:10.1074/jbc.271.12.7160. PMID 8636153.
• Riewald M, Schleef RR (1996). "Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues". J. Biol. Chem. 271 (24): 14526–32. doi:10.1074/jbc.271.24.14526. PMID 8662739.
• Scott FL, Paddle-Ledinek JE, Cerruti L, และคณะ (1999). "Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation". Exp. Cell Res. 245 (2): 263–71. doi:10.1006/excr.1998.4241. PMID 9851866.
• Mikolajczyk SD, Millar LS, Marker KM, และคณะ (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585.
• Saedi MS, Zhu Z, Marker K, และคณะ (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–63. doi:10.1002/ijc.1501. PMID 11745444.
• Wistow G, Bernstein SL, Wyatt MK, และคณะ (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strik MC, Wolbink A, Wouters D, และคณะ (2004). "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers". Blood. 103 (7): 2710–7. doi:10.1182/blood-2003-08-2981. PMID 14670919.
• Ota T, Suzuki Y, Nishikawa T, และคณะ (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, และคณะ (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Charron Y, Madani R, Nef S, และคณะ (2006). "Expression of serpinb6 serpins in germ and somatic cells of mouse gonads". Mol. Reprod. Dev. 73 (1): 9–19. doi:10.1002/mrd.20385. PMID 16175637.
• Rual JF, Venkatesan K, Hao T, และคณะ (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

• ฐานข้อมูลออนไลน์ MEROPS สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส: I04.011
• SERPINB6 protein, human ในหอสมุดแพทยศาสตร์แห่งชาติอเมริกัน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)